It looks like the calpain-10 (CAPN10) gene, aka, the "diabetes gene" might explain the onset of PCOS. A study in the American Journal of Physiology-Endocrinology and Metabolism found three areas of the gene (one expected) showed links to susceptibility to PCOS, and one of those three had a relationship to both type 2 diabetes and PCOS.

Since women with PCOS have an up to seven times greater chance to develop type 2 diabetes than our non-cysters, this is exciting research that may help some of our more stubborn doctors start looking at the IR factor sooner rather than later.